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☐ ☆ ✇ Nature

De novo design of modular peptide-binding proteins by superhelical matching

By: Kejia Wu · Hua Bai · Ya-Ting Chang · Rachel Redler · Kerrie E. McNally · William Sheffler · T. J. Brunette · Derrick R. Hicks · Tomos E. Morgan · Tim J. Stevens · Adam Broerman · Inna Goreshnik · Michelle DeWitt · Cameron M. Chow · Yihang Shen · Lance Stewart · Emmanuel — April 5th 2023 at 00:00

Nature, Published online: 05 April 2023; doi:10.1038/s41586-023-05909-9

A computational approach is used to design modular proteins that bind to synthetic peptides and disordered regions of human proteins with high affinity and specificity.
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