De novo design of modular peptide-binding proteins by superhelical matching

Nature, Published online: 05 April 2023; doi:10.1038/s41586-023-05909-9

A computational approach is used to design modular proteins that bind to synthetic peptides and disordered regions of human proteins with high affinity and specificity.

De novo design of luciferases using deep learning

Nature, Published online: 22 February 2023; doi:10.1038/s41586-023-05696-3

A deep-learning-based strategy is used to design artificial luciferases that catalyse the oxidative chemiluminescence of diphenylterazine with high substrate specificity and catalytic efficiency.