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De novo design of modular peptide-binding proteins by superhelical matching

By: Kejia Wu ยทย Hua Bai ยทย Ya-Ting Chang ยทย Rachel Redler ยทย Kerrie E. McNally ยทย William Sheffler ยทย T. J. Brunette ยทย Derrick R. Hicks ยทย Tomos E. Morgan ยทย Tim J. Stevens ยทย Adam Broerman ยทย Inna Goreshnik ยทย Michelle DeWitt ยทย Cameron M. Chow ยทย Yihang Shen ยทย Lance Stewart ยทย Emmanuel

Nature, Published online: 05 April 2023; doi:10.1038/s41586-023-05909-9

A computational approach is used to design modular proteins that bind to synthetic peptides and disordered regions of human proteins with high affinity and specificity.

As the UN meets, make water central to climate action

By: M. Feisal Rahman ยทย Aditi Mukherji ยทย ร…se Johannessen ยทย Shilpi Srivastava ยทย Joep Verhagen ยทย Henk Ovink ยทย Willem Ligtvoet ยทย Emmanuel Olet

Nature, Published online: 22 March 2023; doi:10.1038/d41586-023-00793-9

Managing water and climate in tandem would protect water resources, reduce disaster risks, lower greenhouse-gas emissions and assure equitable access.

Finding Form


Writing fiction hadnโ€™t been false, for nonfiction isnโ€™t truer than fiction; but Iโ€™d seemed to row at the shallowest region of the narrative stream, where the water wouldnโ€™t reveal its deepest enchantments. I needed to allow the subject to change the form as I progressed. Where I began with curiosity about my uncleโ€™s fate, my travels made me aware of how little of the war had been monumentalized in the Nigerian landscape, ultimately making it necessary for me to define the shape of my work as a reconciliation with the fragmented nature of the past.
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