Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Nature, Published online: 22 February 2023; doi:10.1038/s41586-023-05728-y

Indole-3-acetic acid (3-IAA), a tryptophan metabolite derived from the gut microbiota, is associated with a better response to chemotherapy in pancreatic ductal adenocarcinoma (PDAC), and dietary interventions could have a role in the treatment of PDAC.