Enlarge / A Wendy's old-fashion burger. Romaine lettuce on Wendy's burgers is thought to be the cause of the outbreak. (credit: Getty | Francis Dean)

We will never know for certain what caused a large, multistate outbreak of E. coli O157:H7 infections linked to Wendy's restaurants late last year, according to a new study led by investigators at the Centers for Disease Control and Prevention.

The study, highlighting weaknesses in our ability to respond to foodborne outbreaks, lands amid a separate report published by the CDC finding that, in general, we're also failing to prevent outbreaks. In fact, cases from some common foodborne pathogens have increased relative to pre-pandemic levels.

In the outbreak last year, which spanned from July to August, at least 109 people in six states fell ill, with 52 needing to be hospitalized. Eating at Wendy's was a clear link. But it wasn't enough to crack the case.

Enlarge (credit: Getty | UniversalImagesGroup)

Two more people have died and more details of horrifying eye infections are emerging in a nationwide outbreak linked to recalled eye drops from EzriCare and Delsam.

The death toll now stands at three, according to an outbreak update this week from the Centers for Disease Control and Prevention. A total of 68 people in 16 states have been infected with a rare, extensively drug-resistant Pseudomonas aeruginosa strain linked to the eye drops. In addition to the deaths, eight people have reported vision loss and four have had their eyeballs surgically removed (enucleation).

In a case report published this week in JAMA Ophthalmology, eye doctors at the Bascom Palmer Eye Institute, part of the University of Miami Health System, reported details of one case linked to the outbreak—a case in a 72-year-old man who has an ongoing infection in his right eye with vision loss, despite weeks of treatment with multiple antibiotics. When the man first sought treatment he reported pain in his right eye, which only had the ability to detect motion at the point, while his left eye had 20/20 vision. Doctors noted that the white of his right eye was entirely red and white blood cells had visibly pooled on his cornea and in the front inner chamber of his eye.

Enlarge / Dr. Peter Marks, director of the Center for Biologics Evaluation and Research within the Food and Drug Administration, testifies during a Senate Health, Education, Labor, and Pensions Committee hearing on the federal coronavirus response on Capitol Hill in March 2021, in Washington, DC. (credit: Getty | Pool)

The US Food and Drug Administration's committee of independent vaccine experts gathered Thursday to discuss the future of COVID-19 shots. The meeting seemed primed for explosive debate. Earlier in the week, the FDA released documents that made clear the agency is holding steadfast to its idea that COVID vaccines will fit the mold of annual flu shots—with reformulations decided in the first half of each year, followed by fall rollouts in anticipation of winter waves.

But outside experts, including some on the FDA's advisory committee, have questioned almost every aspect of that plan—from the uncertain seasonality of COVID-19 so far, to the futility of chasing fast-moving variants (or subvariants, as the case may be). Some have even questioned whether there's a need to boost the young and healthy so frequently when current vaccines offer protection against severe disease, but only short-lived protection against infection.

One particularly outspoken member of FDA's committee, Paul Offit, a pediatrician and infectious disease expert at Children’s Hospital of Philadelphia, has publicly assailed the bivalent booster, writing a commentary piece in the New England Journal of Medicine earlier this month titled: Bivalent Covid-19 Vaccines — A Cautionary Tale. (The FDA's advisory committee voted 19-2 in support of the bivalent boosters last year, with Offit being one of the two votes against.)

Enlarge / The Abbott manufacturing facility in Sturgis, Michigan, on May 13, 2022. (credit: Getty | Jeff Kowalsky)

The Department of Justice's consumer-protection branch has opened a criminal investigation into the conduct of Abbott Laboratories, one of the country's largest formula makers at the center of a contamination scandal and ongoing nationwide shortage.

The existence of the investigation was first reported by The Wall Street Journal. Though the DOJ is not commenting on it, a spokesperson for Abbott said the department has informed them of the investigation and that the company is "cooperating fully."

Federal regulators last year found numerous violations and "egregiously unsanitary" conditions at Abbott's Sturgis, Michigan, plant, the largest formula factory in the country. The regulators previously received reports that at least four babies who drank formula made at that facility fell ill with dangerous infections of the bacterium Cronobacter sakazakii, which had also been detected in the plant. Two of the infants died.