Enlarge / A Wendy's old-fashion burger. Romaine lettuce on Wendy's burgers is thought to be the cause of the outbreak. (credit: Getty | Francis Dean)

We will never know for certain what caused a large, multistate outbreak of E. coli O157:H7 infections linked to Wendy's restaurants late last year, according to a new study led by investigators at the Centers for Disease Control and Prevention.

The study, highlighting weaknesses in our ability to respond to foodborne outbreaks, lands amid a separate report published by the CDC finding that, in general, we're also failing to prevent outbreaks. In fact, cases from some common foodborne pathogens have increased relative to pre-pandemic levels.

In the outbreak last year, which spanned from July to August, at least 109 people in six states fell ill, with 52 needing to be hospitalized. Eating at Wendy's was a clear link. But it wasn't enough to crack the case.

Enlarge / One of the medical clinics suspended by Mexican health authorities in Matamoros, Tamaulipas, Mexico, on May 19, 2023. (credit: Getty | AFP)

Three more people in the US have died from fungal meningitis in an outbreak linked to tainted surgeries in Mexico, bringing the total deaths to seven, the Centers for Disease Control and Prevention reported Thursday.

The total case count remains unchanged from an update earlier this month, with 34 cases in the US: nine confirmed, 10 probable, and 15 suspected. Health officials are investigating 161 others who may have been exposed.

The outbreak is linked to cosmetic surgeries involving epidural anesthesia at two clinics in Matamoros, Mexico, just across the border from Brownsville, Texas. Mexican and US officials suspect that a component of the anesthetic was contaminated, resulting in the pathogenic fungus Fusarium solani being injected directly into people's spinal cords. The tainted surgeries are thought to have occurred between January 1, 2023, to May 13, 2023, around when the clinics were shut down by local health officials.

Enlarge / Florida surgeon general Joseph Ladapo speaks at a press conference. (credit: Getty | Paul Hennessy)

Florida health officials deleted key data and statistics from a state analysis on the safety of mRNA COVID-19 vaccines, falsely making them appear unsafe for young men, according to draft versions of the analysis obtained by the Tampa Bay Times through public records requests.

The final analysis, which was widely criticized for its poor quality and dubious conclusions, was the basis for a statewide recommendation by Surgeon General Joseph Ladapo last October that young men, ages 18 to 39, should not receive an mRNA COVID-19 vaccine. The analysis—posted on the Florida Department of Health's website with no authors listed—claimed to find "an 84% increase in the relative incidence of cardiac-related death among males 18-39 years old within 28 days following mRNA vaccination."

Ladapo, who has a history of fearmongering about COVID-19 vaccines, touted the analysis, saying in a press release at the time that "these are important findings that should be communicated to Floridians.”

Enlarge / A person sits at the slot machines at a casino. (credit: Getty | Octavio Jones)

A Tacoma, Washington, woman who has refused court-ordered tuberculosis treatment for over a year is evading arrest and has reportedly taken public transit to go to a casino while on the lam.

The Tacoma-Pierce County Health Department has been trying to get the woman to comply with treatment since at least January 2022, when she received her first court order. Since then, she has received over a dozen court orders for treatment and isolation amid monthly court hearings and order renewals. Last month, Pierce County Superior Court Judge Philip Sorensen finally found her in contempt and issued a warrant for her arrest and involuntary detention at the county jail for treatment and isolation.

"In each case like this, we are constantly balancing risk to the public and the civil liberties of the patient," the health department wrote in a blog post days before the arrest warrant was issued. "We are always hopeful a patient will choose to comply voluntarily. Seeking to enforce a court order through a civil arrest warrant is always our last resort."

Enlarge (credit: Getty | UniversalImagesGroup)

Two more people have died and more details of horrifying eye infections are emerging in a nationwide outbreak linked to recalled eye drops from EzriCare and Delsam.

The death toll now stands at three, according to an outbreak update this week from the Centers for Disease Control and Prevention. A total of 68 people in 16 states have been infected with a rare, extensively drug-resistant Pseudomonas aeruginosa strain linked to the eye drops. In addition to the deaths, eight people have reported vision loss and four have had their eyeballs surgically removed (enucleation).

In a case report published this week in JAMA Ophthalmology, eye doctors at the Bascom Palmer Eye Institute, part of the University of Miami Health System, reported details of one case linked to the outbreak—a case in a 72-year-old man who has an ongoing infection in his right eye with vision loss, despite weeks of treatment with multiple antibiotics. When the man first sought treatment he reported pain in his right eye, which only had the ability to detect motion at the point, while his left eye had 20/20 vision. Doctors noted that the white of his right eye was entirely red and white blood cells had visibly pooled on his cornea and in the front inner chamber of his eye.

Enlarge / A microscope image of Streptococcus pyogenes, a common type of group A strep. (credit: Getty | BSIP)

In the wake of the COVID-19 pandemic and amid a tall wave of respiratory viruses, health officials in Colorado and Minnesota documented an unusual spike in deadly, invasive infections from Streptococcus bacteria late last year, according to a study published this week by the Centers for Disease Control and Prevention.

The spike is yet another oddity of post-pandemic disease transmission, but one that points to a simple prevention strategy: flu shots.

The infections are invasive group A strep, or iGAS for short, which is caused by the same group of bacteria that cause relatively minor diseases, such as strep throat and scarlet fever. But iGAS occurs when the bacteria spread in the body and cause severe infection, such as necrotizing fasciitis (flesh-eating disease), toxic shock syndrome, or sepsis. These conditions can occur quickly and be deadly.

Enlarge / Part of the Brigham and Women's Hospital in Boston on Dec. 16, 2021. (credit: Getty | John Tlumacki)

Water purification systems installed in two ice machines in a Boston hospital were supposed to make the water taste and smell better for patients on a surgery floor—but it ended up killing three of them, an investigation found.

The purification systems inadvertently stripped chlorine from the municipal tap water, allowing bacteria normally found at low levels to flourish and form biofilms inside the machines. This led to infections in four vulnerable cardiac-surgery patients who had prolonged stays on the hospital floor. Three of them died of their infections.

Researchers detailed the case cluster and ensuing investigation in a study published Monday in the Annals of Internal Medicine.

Enlarge / Hughes Memorial Auditorium, where the outpouring event was hosted, on Asbury University's campus in Wilmore, Kentucky. (credit: Asbury University)

The Centers for Disease Control and Prevention on Friday issued a health alert for doctors and health officials to be on the lookout for measles cases after a person with a confirmed, contagious case attended a massive religious event in Kentucky last month, potentially exposing an estimated 20,000 people to one of the most infectious viruses on the planet.

The event was a spontaneous "outpouring" at Asbury University, which drew tens of thousands of worshippers to the small, private Christian institution in Wilmore from February 8 to 23. Attendees came from around Kentucky, other US states, and other countries.

A case of measles was confirmed in an unvaccinated person who had recently traveled out of the country before attending Asbury University's outpouring. The person was at the event from February 17 to 18, the CDC reported. The university added that the person attended before developing symptoms, suggesting the person did not know they were infected. But the CDC notes that people with measles are contagious four days before measles' telltale rash develops, and state health officials said the person was contagious while they were in attendance.

Enlarge / WHO's COVID-19 technical lead, Maria Van Kerkhove, looks on during a press conference at the World Health Organization's headquarters in Geneva, on December 14, 2022. (credit: Getty | FABRICE COFFRINI)

While the World Health Organization says it's continuing to urge China to share data and cooperate with investigations into the origins of SARS-CoV-2, the United Nations' health agency is calling out another country for lack of transparency—the United States.

WHO officials on Friday said that the US has not shared reports or data from federal agencies that have assessed how the COVID-19 pandemic began. That includes the latest report by the Department of Energy, which determined with "low confidence" that the pandemic likely began due to a laboratory accident.

"As of right now, we don't have access to those reports or the data that is underlying how those reports were generated," Maria Van Kerkhove, WHO's technical lead on COVID-19, said in a press briefing Friday. "Again, we reiterate, that any agency that has information on this, it remains vital that that information is shared so that scientific debate, that this discussion, can move forward. Without that, we are not able to move forward in our understanding."

Enlarge / Mycobacterium tuberculosis. (credit: Getty | NIH/NIAID)

A judge in Washington issued an arrest warrant Thursday for a Tacoma woman who has refused to have her active, contagious case of tuberculosis treated for over a year, violating numerous court orders. The judge also upheld an earlier order to have her jailed, where she can be tested and treated in isolation.

On Thursday, the woman attended the 17th court hearing on the matter and once again refused a court order to isolate or comply with testing and treatment—an order that originally dates back to January 19, 2022. Pierce County Superior Court Judge Philip Sorensen rejected her objections to being treated and upheld a finding of contempt. Though it remains unclear what her objections are, the woman's lawyer suggested it may be a problem with understanding, according to The News Tribune. The Tacoma-Pierce County Health Department, however, argued that she “knowingly, willfully, and contemptuously violated this court’s orders,” noting the lengthy process and numerous proceedings and discussions in which interpreters, translated documents, and speakers of her native language were made available.

Sorenson ordered a civil warrant for her arrest, to be enforced on or after March 3, and again ordered her to jail to undergo involuntary testing and treatment until health officials deem it safe to release her. The order also authorized the Pierce County Jail to place her in a facility equipped to handle her isolation, testing, and treatment.

Enlarge / A medical director in Germany sits in front of a monitor showing the real-time data of a patient with a heart attack. (credit: Getty | Arne Dedert)

A bout of COVID-19 is known to increase a person's long-term risks of having a major cardiovascular event, such as a heart attack or stroke. But being fully vaccinated or even partially vaccinated appears to bring that risk down, according to a study published this week in the Journal of the American College of Cardiology.

The study, led by researchers at Icahn School of Medicine at Mount Sinai in New York, drew on medical records from over 1.9 million patients who were infected with COVID-19 between March 2020 and February 2022. Of those 1.9 million patients, a "major adverse cardiac event," namely a heart attack, stroke, or another cardiac event, was identified in 13,948 patients, and 3,175 died following the event.

Overall, the researchers found that being vaccinated—fully or partially—was linked to fewer cardiac events in the six months following a case of COVID-19. After adjusting for demographics, comorbidities, and time since the pandemic began, the researchers found that being fully vaccinated reduced the risk of having a major cardiac event by about 41 percent, while being partially vaccinated reduced the risk by about 24 percent.

Enlarge / Pager, a 9-year-old Macaque, plays MindPong with his Neuralink. (credit: YouTube/NeuraLink)

The US Department of Transportation is investigating allegations that Elon Musk's brain-computer interface company, Neuralink, violated federal transportation regulations when it shipped contaminated implants removed from the brains of deceased research monkeys infected with multiple types of dangerous pathogens. The alleged violations could have put humans at risk of exposure to hazardous germs, including drug-resistant bacteria and a potentially life-threatening herpes virus.

Reuters was the first to report the department's investigation, which was sparked by allegations brought Thursday by the Physicians Committee for Responsible Medicine (PCRM), a medical group that advocates for animal welfare in medical research. The Department of Transportation confirmed to Ars on Friday that it has opened a standard investigation of Neuralink in response to PCRM's allegations.

In a letter addressed to Transportation Secretary Pete Buttigieg and William Schoonover, associate administrator of the department's Pipeline and Hazardous Material Safety Administration, the PCRM laid out its evidence for possible violations of hazardous material transportation regulations based on a trove of documents and emails obtained through public record requests. The advocacy group says the evidence shows Neuralink's contaminated hardware was not properly packaged to prevent exposure to humans and that Neuralink employees who transported the material had failed to undergo legally required training on how to safely transport such material.

Enlarge / People queue for clean water on February 9, 2023, in Hatay, Turkey. (credit: Getty | Burak Kara)

Deaths from the massive earthquake and aftershocks that violently struck parts of southern Turkey and northern Syria in the early hours of Monday have now surpassed 20,000—a staggering toll of devastation.

As of Thursday, Turkey’s national emergency management agency reported more than 17,000 deaths, as well as over 70,000 injured. Syrian Ministry of Health, meanwhile, reported 1,347 deaths and 2,295 injured. Rescuers in rebel-held northwest areas of the country reported at least 2,030 deaths and at least 2,950 injured.

As heroic rescue crews continue sifting through the rubble of collapsed structures, concern is growing for those tens of thousands injured and countless others made more vulnerable by the crisis.

Enlarge / Transmission electron micrograph of poliovirus type 1. (credit: Getty | BSIP)

An eradicated form of wild polio surfaced in routine wastewater monitoring in the Netherlands last year, offering a cautionary tale on the importance of monitoring for the tenacious virus, researchers report this week in the journal Eurosurveilance.

The sewage sample came up positive for infectious poliovirus in mid-November and genome sequencing revealed a strain of wild poliovirus type 3, which was declared globally eradicated in 2019. Its potential revival would be a devastating setback in the decades-long effort to stamp out highly infectious and potentially paralytic germ for good.

For brief background, there are three types of wild polioviruses: type 2 and type 3 have been eradicated, with the former being knocked out in 2015. Wild poliovirus type 1 continues to circulate in Afghanistan and Pakistan. There are also occasional vaccine-derived polioviruses that circulate in communities with low vaccination rates, which recently occurred in New York.

Enlarge / A woman watches white flags on the National Mall on September 18, 2021, in Washington, DC. Over 660,000 white flags were installed here to honor Americans who have lost their lives to COVID-19. (credit: Getty | Chen Mengtong)

Americans spend an exorbitant amount of money on health care and have for years. As a country, the US spends more on health care than any other high-income country in the world—on the basis of both per-person costs and a share of gross domestic product. Yet, you wouldn't know it from looking at major health metrics in years past; the US has relatively abysmal health. And, if anything, the COVID-19 pandemic only exacerbated the US health care system's failures relative to its peers, according to a new analysis by the Commonwealth Fund.

Health care spending of high income-countries by share of GDP. (credit: The Commonwealth Fund)

Compared with other high-income peers, the US has the shortest life expectancy at birth, the highest rate of avoidable deaths, the highest rate of newborn deaths, the highest rate of maternal deaths, the highest rate of adults with multiple chronic conditions, and the highest rate of obesity, the new analysis found.

"Americans are living shorter, less healthy lives because our health system is not working as well as it could be," Munira Gunja, lead author of the analysis and a senior researcher for The Commonwealth Fund’s International Program in Health Policy and Practice Innovation, said in a press statement. "To catch up with other high-income countries, the administration and Congress would have to expand access to health care, act aggressively to control costs, and invest in health equity and social services we know can lead to a healthier population."

Enlarge / US President Joe Biden speaks to members of the media on the South Lawn of the White House in Washington, DC, US, on Monday, Jan. 30, 2023. (credit: Getty | Chris Kleponis/Bloomberg)

President Joe Biden plans to end two national emergency declarations over the COVID-19 pandemic on May 11, which will trigger a restructuring of the federal response to the deadly coronavirus and will end most federal support for COVID-19 vaccinations, testing, and hospital care.

The plan was revealed in a statement to Congress opposing House Republicans' efforts to end the emergency declarations immediately.

“An abrupt end to the emergency declarations would create wide-ranging chaos and uncertainty throughout the health care system—for states, for hospitals and doctors’ offices, and, most importantly, for tens of millions of Americans,” the Office of Management and Budget wrote in a Statement of Administration Policy.

Enlarge / Dr. Peter Marks, director of the Center for Biologics Evaluation and Research within the Food and Drug Administration, testifies during a Senate Health, Education, Labor, and Pensions Committee hearing on the federal coronavirus response on Capitol Hill in March 2021, in Washington, DC. (credit: Getty | Pool)

The US Food and Drug Administration's committee of independent vaccine experts gathered Thursday to discuss the future of COVID-19 shots. The meeting seemed primed for explosive debate. Earlier in the week, the FDA released documents that made clear the agency is holding steadfast to its idea that COVID vaccines will fit the mold of annual flu shots—with reformulations decided in the first half of each year, followed by fall rollouts in anticipation of winter waves.

But outside experts, including some on the FDA's advisory committee, have questioned almost every aspect of that plan—from the uncertain seasonality of COVID-19 so far, to the futility of chasing fast-moving variants (or subvariants, as the case may be). Some have even questioned whether there's a need to boost the young and healthy so frequently when current vaccines offer protection against severe disease, but only short-lived protection against infection.

One particularly outspoken member of FDA's committee, Paul Offit, a pediatrician and infectious disease expert at Children’s Hospital of Philadelphia, has publicly assailed the bivalent booster, writing a commentary piece in the New England Journal of Medicine earlier this month titled: Bivalent Covid-19 Vaccines — A Cautionary Tale. (The FDA's advisory committee voted 19-2 in support of the bivalent boosters last year, with Offit being one of the two votes against.)

Enlarge / A bathroom on an Airbus A321neo. (credit: Getty | Nicolas Economou/NurPhoto)

The US Centers for Disease Control and Prevention is considering blending sewage sampling from airplanes into its wastewater surveillance system, which has proven useful for monitoring the spread and prevalence of a variety of pathogens, particularly SARS-CoV-2.

Amid the pandemic, the CDC launched wastewater testing programs across the nation, trying to get ahead of SARS-CoV-2 surges. Viral particles are often shed in fecal matter and can be an early indication of an infection. The fecal focus has proven useful for sniffing out community-wide transmission trends and disease spread for not only COVID-19 but also other recent outbreaks as well, namely polio and mpox (formerly monkeypox). Adding surveillance from airplanes and airports could flush out yet more information about infectious disease spread, such as global travel patterns and the debut of novel viral variants.

A study published last week in PLOS Global Public Health found such sewage surveillance in UK airport terminals and airplanes was effective at tracking SARS-CoV-2 among international travelers. Overall, the surveillance data suggested that it is a "useful tool for monitoring the global transfer rate of human pathogens and other disease-causing agents across international borders and should form part of wider international efforts to monitor and contain the spread of future disease outbreaks," the authors, led by Kata Farkas of Bangor University, concluded.

Enlarge / Chicken eggs are disposed of at a quarantined farm in Israel's northern Moshav (village) of Margaliot on January 3, 2022. (credit: Getty | JALAA MAREY / AFP))

The ongoing bird flu outbreak in the US is now the longest and deadliest on record. More than 57 million birds have been killed by the virus or culled since a year ago, and the deadly disruption has helped propel skyrocketing egg prices and a spike in egg smuggling.

Since highly pathogenic avian influenza (HPAI) A(H5N1) was first detected in US birds in January 2022, the price of a carton of a dozen eggs has shot up from an average of about $1.79 in December 2021 to $4.25 in December 2022, a 137 percent increase, according to data from the US Bureau of Labor Statistics. Although inflation and supply chain issues partly explain the rise, eggs saw the largest percentage increase of any specific food, according to the consumer price index.

And the steep pricing is leading some at the US-Mexico border to try to smuggle in illegal cartons, which is prohibited. A US Customs and Border Protection spokesperson told NPR this week that people in El Paso, Texas, are buying eggs in Juárez, Mexico, because they are "significantly less expensive." Meanwhile, a customs official in San Diego tweeted a reminder amid a rise in egg interceptions that failure to declare such agriculture items at a port of entry can result in penalties up to $10,000.

Enlarge / The Abbott manufacturing facility in Sturgis, Michigan, on May 13, 2022. (credit: Getty | Jeff Kowalsky)

The Department of Justice's consumer-protection branch has opened a criminal investigation into the conduct of Abbott Laboratories, one of the country's largest formula makers at the center of a contamination scandal and ongoing nationwide shortage.

The existence of the investigation was first reported by The Wall Street Journal. Though the DOJ is not commenting on it, a spokesperson for Abbott said the department has informed them of the investigation and that the company is "cooperating fully."

Federal regulators last year found numerous violations and "egregiously unsanitary" conditions at Abbott's Sturgis, Michigan, plant, the largest formula factory in the country. The regulators previously received reports that at least four babies who drank formula made at that facility fell ill with dangerous infections of the bacterium Cronobacter sakazakii, which had also been detected in the plant. Two of the infants died.