Nature, Published online: 05 April 2023; doi:10.1038/s41586-023-05933-9
Cryo-electron microscopy analysis of the Deinococcus radiodurans ISDra2 TnpB in complex with its cognate ฯRNA and target DNA provides insights into the mechanism of TnpB function and the evolution of CRISPRโCas12 effectors.