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Structure and thiazide inhibition mechanism of the human Na–Cl cotransporter
February 15^th 2023 at 00:00

Structure and thiazide inhibition mechanism of the human Na–Cl cotransporter

By: Minrui Fan · Jianxiu Zhang · Chien-Ling Lee · Jinru Zhang · Liang Feng

Nature, Published online: 15 February 2023; doi:10.1038/s41586-023-05718-0

Using cryo-electron microscopy, the structures of human Na–Cl cotransporter are determined alone and in complex with a thiazide diuretic.

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February 15^th 2023 at 00:00